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Updated: Jul 14, 2026

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
07:44

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通过对烯衍生物的双光监测DNA结构

Akimitsu Okamoto1, Kazuki Tainaka, Ken-ichiro Nishiza

  • 1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan. okamoto@sbchem.kyoto-u.ac.jp

Journal of the American Chemical Society
|September 22, 2005
PubMed
概括

研究人员创造了一种新的光核酸探针,可以改变颜色以信号DNA杂交. 这种双光核酸盐提供了一种更简单的方法来监测DNA结构变化,而不需要多个光标签.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...