这是一种Plasmodium vivax merozoites的网状细胞结合蛋白复合体
M R Galinski1, C C Medina, P Ingravallo
1Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10010.
Cell
|June 26, 1992
概括
鉴定出了两个新的Plasmodium vivax网细胞结合蛋白 (PvRBPs). 这些蛋白质特别粘附于网状细胞,解释了寄生虫更喜欢入侵这些细胞的原因.
科学领域:
- 疟疾学 疟疾学
- 分子寄生虫学 分子寄生虫学
- 细胞生物学 细胞生物学
背景情况:
- 活性等性菌 (Plasmodium vivax merozoites) 呈现出强烈的偏好入侵网状细胞,一个特定的红细胞亚型.
- 在P. vivax入侵中这种宿主细胞特异性的基础上的分子机制仍然不完全理解.
研究的目的:
- 为了识别和描述参与P. vivax网细胞入侵的新型蛋白质.
- 阐明这些蛋白质在调解宿主细胞结合和入侵特异性的作用.
主要方法:
- 对两种新型P. vivax蛋白质PvRBP-1和PvRBP-2的鉴定和表征.
- 对相关的Plasmodium物种基因同质性的分析,具有不同的网细胞入侵偏好.
- 蛋白质定位和功能的生物化学分析.
主要成果:
- 确定了两个新的P.vivax蛋白质PvRBP-1和PvRBP-2,它们在 merozoite的顶极上同定位.
- 这些蛋白质被证明特别粘附于网细胞.
- 在P. cynomolgi (网细胞入侵) 中发现了同源基因,但在P. knowlesi (入侵所有红细胞) 中没有发现.
- PvRBP-1很可能是一个跨膜定蛋白质,两者都可能形成一个复合体.
结论:
- PvRBP-1和PvRBP-2是P. vivax网状细胞入侵的关键媒介.
- 这些网细胞结合蛋白 (RBPs) 可能起到粘合复合体的作用,以准网细胞.
- 同源RBPs的存在/缺失与Plasmodium物种的网细胞入侵特异性相关.
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