定期进行体育炼和低脂肪饮食. 对冠状动脉疾病进展的影响
G Schuler1, R Hambrecht, G Schlierf
1Department of Cardiology, Medizinische Universitätsklinik, Heidelberg, Germany.
Circulation
|July 1, 1992
概括
强烈的体力炼和低脂肪饮食减缓了冠状动脉疾病的进展,稳定性胸痛患者. 与常规护理相比,这种生活方式干预改善了冠状动脉形态和心肌 perfusion.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 运动生理学 运动生理学
背景情况:
- 冠状动脉疾病 (CAD) 的管理通常涉及降脂疗法.
- 以前的研究表明动脉样硬化病变回归与积极的脂质降低.
- 生活方式干预对稳定性 angina 的 CAD 进展的影响需要进一步研究.
研究的目的:
- 评估强烈的体力炼和低脂肪饮食对冠状动脉形态和心肌 perfusion 的影响.
- 评估这些生活方式变化的适用性在非选择性患有稳定性胸痛的患者中.
主要方法:
- 随机对照试验包括113名被诊断患有稳定胸痛的患者.
- 干预组:强烈的体力炼 (团体和家庭) 和12个月的低脂肪,低胆固醇饮食.
- 控制组:接受"通常的护理".
- 冠状动脉血管学和201Tl光阴学被用于评估病变进展和心肌 perfusion.
主要成果:
- 干预组表现出显著的改善:体重减少5%,总胆固醇减少10%,甘油三降低24%,体力工作能力增加23%.
- 冠状动脉病变在干预组的32%,对照组的17% (p <0.05) 呈现回归.
- 与对照组 (48%) 相比,干预组 (23%) 的冠状动脉病变进展较少.
结论:
- 定期体育炼和低脂肪饮食可以显著减缓冠状动脉疾病的进展在患有稳定性 angina 的患者.
- 生活方式干预提供了一个可行的替代方案或辅助药理疗法来管理CAD.
- 结合生活方式干预观察到冠状动脉形态和心肌输液的改善.
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