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Updated: Jul 21, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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PKR和eIF2alpha:整合激酶二分化,激活和基质对接

Susan S Taylor1, Nina M Haste, Gourisankar Ghosh

  • 1Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093, USA.

Cell
|September 24, 2005
PubMed
概括

依赖RNA的蛋白激酶 (PKR) 结合病毒RNA阻止蛋白质合成. 结构研究揭示了PKR如何二元化以激活和结合其基质eIF2alpha,从而使抗病毒防御成为可能.

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