埃克迪松和胰岛素的对抗作用决定了Drosophila的最终尺寸
Julien Colombani1, Laurence Bianchini, Sophie Layalle
1CNRS/University of Nice-Sophia Antipolis, UMR6543, Parc Valrose, 06108 Nice Cedex 2, France.
Science (New York, N.Y.)
|September 24, 2005
概括
昆虫的生长是由胰岛素信号传递和类固醇激素20-hydroxyecdysone (20E) 之间的平衡来调节的. 20E通过阻碍胰岛素信号来抑制生长,建立一个关键的激素循环来确定生物体的大小.
科学领域:
- 发育生物学是发展生物学.
- 内分泌学 在内分泌学.
- 分子遗传学 分子遗传学
背景情况:
- 动物协调成长和成熟,以最终的尺寸和形状.
- 胰岛素家族分子调节昆虫的生长和新陈代谢.
- 类固醇20-hydroxyecdysone (20E) 在昆虫中引发主要的发育过渡.
研究的目的:
- 研究20E信号在控制动物生长速度中的作用.
- 阐明20E影响生长的分子机制.
- 为了确定参与依赖于ecdysone的生长调节的关键组织.
主要方法:
- 对胰岛素信号通路的分析.
- 研究转录因子局部化 (dFOXO).
- 对基因转录的测量 (4E-BP).
- 研究幼虫脂肪体在生长调节中的作用.
主要成果:
- 20E信号负控制动物生长速度.
- 20E通过影响dFOXO定位来阻碍一般胰岛素信号传递.
- 20E信号减少了翻译抑制剂4E-BP的转录.
- 幼虫脂肪体作为依赖于ecdysone的生长抑制的关键中继器.
结论:
- 埃克迪松可以抵消胰岛素促进生长的作用.
- 包括ecdysone和胰岛素在内的幽默调节循环决定了生物体的大小.
- 这种荷尔蒙相互作用对于协调昆虫的发育和生长至关重要.
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