氧化和手术伤口感染的风险:一项随机试验
Edith Fleischmann1, Rainer Lenhardt, Andrea Kurz
1Department of Anaesthesia and Intensive Care Medicine, Medical University Vienna, Vienna, Austria.
Lancet (London, England)
|September 27, 2005
概括
氧化不会增加手术伤口感染的风险. 这项研究发现,在结肠切除手术期间,接受氧化和接受的患者之间的感染率没有显著差异.
科学领域:
- 麻醉学 麻醉学
- 外科手术的结果
- 传染性疾病 传染性疾病
背景情况:
- 氧化会损害维生素B12和氨酸合成酶,影响DNA和细胞形成.
- 它抑制了氨酸的产生,可能减少痕形成和单细胞迁移.
- 该研究调查了氧化对手术伤口感染率的影响.
研究的目的:
- 为了确定手术内施用氧化是否会增加手术伤口感染的发生率.
- 在接受结肠切除的患者中比较术后伤口感染率.
主要方法:
- 418名接受结肠切除的患者被随机分配给接受65%的手术内氧化或.
- 主要结局是临床术后伤口感染的发生率.
- 分析是根据治疗意图进行的.
主要成果:
- 氧化组的感染率为15%,组的感染率为20% (p=0.205).
- 在ASEPSIS伤口愈合得分,原沉积,ICU入院,第一次摄入食物的时间,住院时间或群体之间的死亡率方面没有发现显著差异.
- 在氧化组中,手术的持续时间较短.
结论:
- 在手术期间使用氧化并不会增加手术伤口感染的发生率.
- 这些发现表明,氧化可以在这种手术环境中安全地使用,而不会增加感染风险.
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