高胆固醇血症通过意识子的四水生物胺依赖机制取消了晚期预条件
Xian-Liang Tang1, Hitoshi Takano, Yu-Ting Xuan
1Institute of Molecular Cardiology, University of Louisville, The Jewish Hospital Heart and Lung Institute, Louisville, KY, USA.
Circulation
|September 28, 2005
概括
高胆固醇血清症通过抑制四二素 (BH4) 上调来阻断晚期缺血预条件 (PC) 的心脏保护作用. 这种机制对于在没有高胆固醇的情况下维持心脏保护至关重要.
科学领域:
- 心血管生理学心血管生理学
- 分子心脏病学分子心脏病学
- 缺血性心脏病是一种心脏病.
背景情况:
- 晚期缺血预调 (PC) 在健康模型中提供心脏保护.
- 高胆固醇血症对晚期PC的影响尚不清楚.
- 四基生物素 (BH4) 是心血管功能中的关键辅因子.
研究的目的:
- 调查高胆固醇血症是否会影响晚期PC的心脏病缓解效果.
- 确定BH4依赖性途径是否调解高胆固醇血症中晚期PC的丧失.
主要方法:
- 具有正常或高胆固醇饮食的有意识的子接受了缺血性PC.
- 冠状动脉封闭和再注血协议被用于诱导心肌梗塞.
- 评估了BH4水平和BH4合成抑制剂 (N-乙血) 的作用.
主要成果:
- 在正常胆固醇贫血的子中,PC降低了心脏病发作的大小,增加了心肌BH4.
- 在高胆固醇贫血的子中,PC未能减少心脏病发作的大小或增加BH4.
- 抑制BH4合成消除了PC在正常胆固醇贫血子中的保护作用.
结论:
- 高胆固醇血症取消了晚期PC的抗心脏病效应,并削弱了BH4上调.
- 抑制BH4合成模仿高胆固醇血症对晚期PC的影响.
- 高胆固醇血症通过阻止BH4上调节来损害晚期PC,这对于可诱导的氧化合成酶至关重要.
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