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使用β-甲基-p-[(123) I]-二-五甲酸的代谢成像识别了需求缺血后缺血记忆

Vasken Dilsizian¹, Timothy M Bateman, Steven R Bergmann

¹Division of Nuclear Medicine, University of Maryland Hospital and School of Medicine, Baltimore, MD 21201-1595, USA. vdilsizian@umm.edu

|September 28, 2005

概括

贝塔-甲基-p-[(123) I] - आयो多-五甲酸 (BMIPP) 成像有效地识别了最近因运动引起的心肌缺血症的患者. 这种代谢成像技术揭示了持续的代谢变化,或缺血性记忆,紧张诱导的缺血性情节后.

科学领域:

心脏病学心脏病学
核医学就是核医学.
医疗成像医学成像

背景情况:

心肌缺血可能导致脂肪酸代谢的长期抑制,称为代谢麻醉,即使在恢复血液流动后.
β-甲基-p-[(123) I]-基-甲基酸 (BMIPP) 是一种分支链脂肪酸追踪剂,其潜力在识别缺血后持续的代谢变化方面得到了研究.

研究的目的:

评估BMIPP SPECT成像在检测肌肉心脏缺血症在运动诱发发作后长达30小时的疗效.
评估BMIPP吸收和 perfusion 缺陷之间的相关性.

主要方法:

32名运动诱导性缺血症患者在缺血事件发生后30小时内接受了BMIPP SPECT静止成像.
在BMIPP注射后获得了早期 (10分钟) 和延迟 (30分钟) 的SPECT图像.
三名失明观察员独立分析了BMIPP和SPECT数据.

主要成果:

BMIPP成像显示出与 SPECT在识别异常方面具有很高的一致性 (91%早期,94%延迟).
无论成像是在缺血后的同一天 (95%) 还是第二天 (91%) 进行,一致性仍然很高.
休息时的BMIPP代谢缺陷的大小与运动诱导的 perfusion缺陷有显著的相关性 (r=0.6,P<0.001早期;r=0.5,P=0.005延迟).

结论:

使用BMIPP进行代谢成像是有效的识别患者最近的运动诱导的心肌缺血.
BMIPP成像成功地可视化了缺血期的代谢后果,称为"缺血记忆".

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