饮食中的植物雌激素和肺癌风险
Matthew B Schabath1, Ladia M Hernandez, Xifeng Wu
1Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston 77230-1439, USA.
JAMA
|September 29, 2005
概括
饮食中摄入较高的植物雌激素,包括植物,异黄和灵,与肺癌风险降低有关. 这些保护作用在男性和女性吸烟者以及非吸烟者中都被观察到.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 饮食科学 饮食科学
背景情况:
- 在体外和体内研究表明,植物性雌激素在预防肺癌方面发挥着作用.
- 有限的流行病学研究存在于饮食中的植物雌激素摄入量和肺癌风险.
研究的目的:
- 调查饮食中植物雌激素消费与患肺癌的风险之间的关联.
主要方法:
- 一项美国病例控制研究,涉及1674名肺癌患者和1735名对照.
- 通过使用食物频率调查问卷量化了12种单个植物雌激素的饮食摄入量.
- 使用无条件多变量逻辑回归分析来估计肺癌风险,调整为混因素.
主要成果:
- 增加总植物雌激素,植物醇,异黄和灵的摄入量与降低肺癌风险相关.
- 总植物雌激素摄入量的最高四分位数显示46%的风险降低 (OR,0.54;95% CI,0.42-0.70).
- 发现了性别特异性差异,男性显示出所有植物雌激素组的显著趋势,女性显示出仅来自食物来源的植物雌激素总量的显著趋势.
结论:
- 这项研究为植物雌激素摄入量与降低肺癌风险之间的联系提供了流行病学支持.
- 需要通过大规模的前性研究进一步证实,以验证这些发现.
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