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Updated: Jul 5, 2026

Efficient and Site-specific Antibody Labeling by Strain-promoted Azide-alkyne Cycloaddition
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伊索埃杜诺和β-阿雷诺的全合成,采用了非常规的策略和方法

Jason S Kingsbury1, E J Corey

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|October 6, 2005
PubMed
概括

一种新的合成策略使得多拉贝兰海产天然产品,特别是β-烯和isoedunol的酶选择性合成成为可能. 这种途径利用了诸如二聚选择性化和库林科维奇乙烯化等关键步骤,以实现高效的构造.

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...