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Updated: Jul 17, 2026

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
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含有8-oxoguanine的DNA基因对的动态行为

Xiaolin Cheng1, Catherine Kelso, Viktor Hornak

  • 1Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, USA.

Journal of the American Chemical Society
|October 6, 2005
PubMed
概括

DNA氧化,特别是8-oxoguanine (8-oxoG),增加了DNA的灵活性,并促进了基底挤出. 像8-oxoG:A这样的不匹配物经历自发的反-至-syn转换,影响DNA修复酶的选择性.

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