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年龄和性别相关的腹腔血管硬化:一个基于社区的研究
Margaret M Redfield1, Steven J Jacobsen, Barry A Borlaug
1Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA. redfield.margaret@mayo.edu
Circulation
|October 6, 2005
概括
随着年龄的增长和女性的性别增加了血管和心室的硬,即使没有心血管疾病. 这种与年龄相关的硬化可能解释了老年妇女中心力衰竭的更高患病率与保存的射出分数.
科学领域:
- 心血管生理学心血管生理学
- 老年医学 老年医学
- 生物医学工程 生物医学工程
背景情况:
- 随着年龄的增长,心力衰竭与保存的喷射分数 (HFnlEF) 越来越普遍,特别是在女性中.
- 增加的血管 (Ea),心室缩 (Ees) 和腹缩 (Ed) 弹性 (刚性) 都与HFnlEF的发病有关.
- 假设与年龄相关的腹腔血管硬,在女性中可能更为明显.
研究的目的:
- 调查年龄和性别与社区人口中的血管和心室硬的关联.
- 为了确定心室血管硬化是否会随着年龄的增长而发生,并且在女性中更明显.
- 在已知心血管疾病或没有心血管疾病的个体中检查这些关联.
主要方法:
- 对2042名45岁及以上的奥尔姆斯特德县居民进行横截面研究.
- 收集了临床数据,多普勒心声图和血压测量.
- 血管弹性 (EaI),心室缩弹性 (Ees) 和心室缩弹性 (Ed) 均使用经过验证的方法来计算.
主要成果:
- 随着年龄的增长,男性和女性的血管 (EaI),心室缩 (Ees) 和腹缩 (Ed) 弹性增加 (P<0.0001).
- 在女性中,心室缩弹性 (Ees) 随着年龄的增长而更急剧增加 (P=0.002).
- 经过年龄调整,女性的EaI,Ees和Ed显著高于男性 (P<0.0001).
结论:
- 晚年和女性性别独立地与一般社区的血管和心室硬度增加有关.
- 即使没有确诊的心血管疾病,这些硬化效应也存在.
- 结合腹腔血管硬化可能导致老年人,特别是女性中HFnlEF的发病率更高.
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