血管内皮生长因子对于大鼠的冠状动脉附带生长是必要的
Eiji Toyota1, David C Warltier, Tommy Brock
1Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Circulation
|October 6, 2005
概括
血管内皮生长因子 (VEGF) 对冠状动脉附带生长至关重要. 在老鼠中阻断VEGF阻止了重复性缺血后新血管的发育,证实了其至关重要的作用.
科学领域:
- 心血管生物学 心血管生物学
- 血管新生研究研究
- 缺血性心脏病模型
背景情况:
- 冠状动脉附带生长与血管内皮生长因子 (VEGF) 相关.
- 以前的研究表明存在联系,但没有确定VEGF在附带发展中的因果关系.
- 了解VEGF的作用对于针对冠状动脉疾病的治疗策略至关重要.
研究的目的:
- 确定血管内皮生长因子 (VEGF) 表达是否对冠状动脉附带生长至关重要.
- 研究VEGF与心脏新血管的发展之间的因果关系.
主要方法:
- 在10天的时间里,在老鼠中诱导了重复性心肌缺血 (RI).
- 通过测量放射性微球的血液流量来评估附带生长.
- 使用X射线微型CT可视化了动脉-动脉瘤.
- 动物被分为假,RI和RI与抗VEGF治疗组.
主要成果:
- 重复性缺血症 (RI) 增加了大约六倍的附带血流.
- 用抗VEGF的治疗完全阻止了附带血流的增加和新的动脉动脉动脉动脉动脉动脉的形成.
- 在RI组的附带生长是功能性的,在闭塞期间保持心脏功能,与抗VEGF组不同.
结论:
- 血管内皮生长因子 (VEGF) 表达对冠状动脉附带体的生长至关重要.
- 在功能性冠状动脉附带循环的发展中,VEGF起着因果作用.
- 向VEGF可能是一个可行的策略,以促进缺血性心脏病的附带增长.
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