多重原发性黑色素瘤的临床病理特征和风险因素
Cristina R Ferrone1, Leah Ben Porat, Katherine S Panageas
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
JAMA
|October 6, 2005
概括
患有黑色素瘤病史和特定风险因素的患者,如家族病史或缺血性瘤,患多发性原发性黑色素瘤 (MPM) 的发生率更高. 通过密集查及早检测对于这些高危人群至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 多发性初级黑色素瘤 (MPM) 的发病率各不相同,现有研究对特定的风险因素缺乏明确性.
- 了解这些因素对于有效的患者管理和风险分层至关重要.
研究的目的:
- 为了确定多发性初级黑色素瘤 (MPM) 的发病率,使用前性,单一机构的数据库.
- 确定与MPM相关的临床和病理特征以及特定的风险因素.
- 分析后续原发性黑色素瘤的发展风险.
主要方法:
- 纪念斯隆-凯特林癌症中心多学科数据库的前性审查.
- 分析了在1996年至2002年期间被诊断出第一个原发性黑色素瘤的4484名患者.
- 识别和评估MPM发展的风险因素,包括家族病史和缺血性瘤.
主要成果:
- 患MPM的发病率为8.6%,平均每名患者患有2.3种黑色素瘤.
- 与单一原发性黑色素瘤 (SPM) 患者相比,具有阳性家族病史 (21%) 或异形瘤 (38%) 的患者的MPM发病率显著更高 (分别为12%和18%).
- 第二次原发性黑色素瘤的5年风险总体为11.4%,在家族病史呈阳性的人群中增加到19.1%,在异形性瘤患者中增加到23.7%.
结论:
- 积极的家族病史和/或缺血性瘤的存在是发展多发性原发性黑色素瘤的重要危险因素.
- 鉴定出这些风险因素的患者需要进行密集的皮肤学查.
- 对于患有多发性初级黑色素瘤风险增加的个体,应考虑进行基因检测.
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