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遗传流行病学和公共卫生:希望,作和未来的前景
George Davey Smith1, Shah Ebrahim, Sarah Lewis
1Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK. zetkin@bristol.ac.uk
Lancet (London, England)
|October 26, 2005
概括
遗传流行病学正在进步,但其对健康的影响尚不清楚. 门德尔随机化可以将环境因素与疾病联系起来,帮助预防策略.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 遗传流行病学是一个不断发展的领域,其健康影响尚不清楚.
- 分子遗传查是为单一性疾病而建立的,而不是复杂疾病.
- 使用基因测试治疗常见疾病的个性化药物发展不足.
研究的目的:
- 澄清遗传流行病学对健康的影响.
- 探索遗传流行病学在确定环境风险因素方面的作用.
- 突出未来技术进步和生物银行的潜力.
主要方法:
- 审查遗传流行病学的当前应用和局限性.
- 关于因果推理的门德尔随机化的讨论.
- 强调基于人口的资源 (生物库) 的作用.
主要成果:
- 遗传流行病学对个人和人口健康的直接影响仍然不确定.
- 目前的基因查和个性化医学仅限于复杂疾病.
- 门德尔随机化提供了一种途径,以确定可修改的风险因素的因果关系.
结论:
- 遗传流行病学具有了解复杂疾病和告知预防的潜力.
- 技术和生物银行的进步对于实现这一潜力至关重要.
- 需要进一步的研究来将遗传发现转化为可行的健康策略.
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