遗传预测因素和在肌肉衰竭中扩张性心肌病变的重塑

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Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice
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John L Jefferies1, Benjamin W Eidem, John W Belmont

  • 1Department of Cardiology, Texas Heart Institute, St Luke's Episcopal Hospital, Houston, Texas, USA.

Circulation
|October 26, 2005
PubMed
概括

在杜氏肌力发育不良 (DMD) 和贝克尔肌力发育不良 (BMD) 患者中早期诊断和治疗扩张性心肌病 (DCM) 可能导致心室重塑. 特定的双基因突变与DCM的发展相关,而其他突变可能会提供保护.

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