种族和外围动脉疾病:圣地亚哥人口研究
Michael H Criqui1, Veronica Vargas, Julie O Denenberg
1Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA. mcriqui@ucsd.edu
Circulation
|October 26, 2005
概括
黑人种族是外围动脉疾病 (PAD) 的独立风险因素,即使考虑到其他健康状况. 黑人中较高的PAD发病率仍然无法解释,需要进一步调查.
科学领域:
- 心血管流行病学心血管流行病学
- 血管健康差异的差异
背景情况:
- 之前的研究表明,与非西班牙裔白人 (NHWs) 相比,黑人人口的外周动脉疾病 (PAD) 率更高.
- 关于西班牙裔和亚洲人群中PAD患病率的数据有限.
- 黑人患PAD风险增加的根本原因尚不清楚.
研究的目的:
- 确定四个主要族群的种族特异性PAD流行率.
- 调查黑人种族与PAD风险之间的关联,独立于其他风险因素.
主要方法:
- 一项以人口为基础的研究评估了来自四个种族的29-91岁的2343名参与者:NHW,黑人,西班牙裔和亚洲人.
- 使用加权后勤回归模型来分析PAD患病率和相关风险因素.
- 人口因素,糖尿病,高血压和体重指数都被纳入了分析.
主要成果:
- 整体PAD患病率为4.4% (104例).
- 与NHW相比,黑人个人表现出明显更高的PAD患病率 (OR=2.30),独立于人口因素.
- 西班牙裔和亚洲人的PAD发病率与NHWs没有显著差异.
- 在黑人中观察到更高的糖尿病,高血压和体重指数,但这些并不能解释PAD风险的增加.
- 黑人种族和其他危险因素之间没有发现显著的相互作用,这表明没有增加的易感性.
结论:
- 黑人种族是PAD的重要和独立的风险因素.
- 黑人中PAD风险过高的原因并不是糖尿病,高血压或体重指数较高.
- 黑人群体中PAD无法解释的过度风险需要进一步的研究来确定潜在的原因.
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