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Updated: Jul 16, 2026

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EPR距离测量支持E. coli核糖核酸还原酶中远程基因启动的模型

Marina Bennati1, John H Robblee, Veronica Mugnaini

  • 1Institute of Physical and Theoretical Chemistry and BMRZ, University of Frankfurt, D-60439 Frankfurt, Germany. bennati@chemie.uni-frankfurt.de

Journal of the American Chemical Society
|October 27, 2005
PubMed
概括

研究人员测量了大肠杆菌核糖核酸减少酶子单元R1和R2之间的距离. 使用一种新的抑制剂和先进的技术,他们发现距离为48 Å,证实了结构模型.

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Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...