心脏热素的升高,心血管疾病,和下大脑下下垂体出血后的结果
Andrew M Naidech1, Kurt T Kreiter, Nazli Janjua
1Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Circulation
|November 4, 2005
概括
在下大脑下出血 (SAH) 后心脏素I (cTI) 的升高是常见的,并且与神经性心肌损伤有关. 较高的CTI水平与心肺问题风险增加以及医院出院后的结果更差相关.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 关键护理医学 关键护理医学
背景情况:
- 心脏中素I (cTI) 释放在下关节出血 (SAH) 后很常见,这表明神经性心肌损伤.
- 这些cTI升高的预后意义还不清楚.
研究的目的:
- 为了研究心脏托波宁I在下大脑下出血后升高的临床影响和预后意义.
主要方法:
- 在253名SAH患者中进行了连续cTI测量,这些患者有临床或心电图心脏损伤的迹象.
- 预期记录了住院事件和3个月后的结果 (修改的兰金尺度).
- 分析了与各种临床和心声学参数相关的cTI峰值水平.
主要成果:
- 对于cTI升高的入院预测因素包括临床等级差,心室内出血和意识丧失.
- 峰值cTI水平与左心室功能障碍,肺,低血压和延迟脑缺血的风险增加有关.
- 升高的cTI预测了住院死亡或严重残疾 (调整的OR,每五分之一1.4;P=0.02).
结论:
- 在SAH后心脏托波宁I的升高与心肺复发症的风险更高有关.
- 升高的cTI也与延迟的脑缺血和医院出院时较差的功能结果有关.
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