霍克斯监管网络建立了运动神经元池的身份和目标肌肉连接
Jeremy S Dasen1, Bonnie C Tice, Susan Brenner-Morton
1Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, NY 10032, USA.
Cell
|November 5, 2005
概括
霍克斯转录调节网络决定了脊柱运动神经元池的身份和肌肉连接. 这种网络建立了面尾的定位和细分的多样性,这对神经元的特异性至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 脊柱运动神经元表现出专门的池身份,使得选择性连接与目标肌肉.
- 这种神经元特异性背后的分子机制在很大程度上是未知的.
研究的目的:
- 阐明脊柱运动神经元池身份和连接的分子基础.
- 研究霍克斯基因在指定运动神经元特征中的作用.
主要方法:
- 在脊柱运动神经元内对Hox转录调节网络的分析.
- 调查相互依存的霍克斯监管相互作用.
- 检查下游的转录目标和肌肉连接模式.
主要成果:
- 一个霍克斯转录调节网络被确定为运动神经元池身份的关键决定因素.
- 发现了两组霍克斯相互作用:一个用于 rostrocaudal 位置,另一个用于细分多样性.
- 这个网络指导着运动神经元池的转录身份和目标肌肉连接.
结论:
- 霍克斯基因在确定脊柱运动神经元池身份方面发挥着至关重要的作用.
- 已识别的霍克斯调节网络为了解运动电路中的神经元特异性提供了一个分子框架.
- 这一发现揭示了控制运动神经元与肌肉连接的发育过程.
相关概念视频
Motor Units
63.3K
A motor unit consists of two main components: a single efferent motor neuron (i.e., a neuron that carries impulses away from the central nervous system) and all of the muscle fibers it innervates. The motor neuron may innervate multiple muscle fibers, which are single cells, but only one motor neuron innervates a single muscle fiber.
63.3K
Master Transcription Regulators
8.0K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
8.0K
Formation of Muscle Fibers from Myoblasts
7.4K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
7.4K
The Neuromuscular Junction
24.0K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
24.0K
Motor Units
10.5K
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
Motor units come in different sizes, with smaller units...
10.5K
Hierarchy of Motor Control
6.9K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
6.9K


