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Updated: Jul 6, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

乘客链裂变有助于将siRNA组装成含Ago2的RNAi酶复合体

Christian Matranga1, Yukihide Tomari, Chanseok Shin

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Cell
|November 8, 2005
PubMed
概括

Argonaute2 (Ago2) 直接与双链小干扰RNA (siRNA) 结合,并分裂乘客链,使导链能够纳入RNA诱导沉默复合体 (RISC). 这种机制对于siRNA介导的基因沉默至关重要.

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