虫[n]uril家族:自排序系统的主要组件
Simin Liu1, Christian Ruspic, Pritam Mukhopadhyay
1Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Journal of the American Chemical Society
|November 10, 2005
概括
黄瓜[n]urils (CB[n]) 在宿主-客人复杂化中表现出显著的尺寸和形状选择性. 较大的CB[n]变种,如CB[7]和CB[8],保持CB[6][6]的状态.
科学领域:
- 超分子化学 超分子化学
- 主机和客人的化学反应
- 分子识别分子识别
背景情况:
- 黄瓜[n]urils (CB[n]) 是宏环宿主,以其独特的腔结构而闻名.
- 了解不同CB[n]同类的结合亲和性和选择性对于设计先进的分子系统至关重要.
研究的目的:
- 量化各种宿主-客体综合体的结合常数 (Ka),其中包括子[n]urils (CB[6]-CB[8]).
- 与CB相比,研究CB[7]和CB[8]的尺寸,形状和功能组选择性[6].
- 探索CB[n]家族的集体选择性,以在自我排序系统中潜在的应用.
主要方法:
- 使用1H NMR竞争实验来确定约束常数.
- 紫外线/紫外线定位被用于确定绝对约束常量作为参考.
- 分析的重点是CB[6],CB[7],CB[8],以及各种阿达曼坦衍生物和其他客体之间的相互作用.
主要成果:
- CB[7]和CB[8]的选择性与CB[6]相似,CB[7]有效地容纳三甲基基.
- 对于CB的结合常量[7]与阿达曼坦衍生物22-24的结合常量超过了10^12 M^-1.
- 观察到高集体选择性,根据客人结构对CB[7]和CB[8]的偏好不同.
结论:
- 该CB[n]家族表现出高度的个人和集体选择性,使它们对分子识别有价值.
- 显著的结合亲和性和选择性将CB[n]定位为开发功能生物模拟自我分类系统的关键组件.
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