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相关概念视频

Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.

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相关实验视频

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Preparation of Drosophila Polytene Chromosome Squashes for Antibody Labeling
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通过JNK信号抑制Polycomb组蛋白质,可以诱导Drosophila影像盘中的转定性.

Nara Lee1, Cédric Maurange, Leonie Ringrose

  • 1Centre for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, 69120 Heidelberg, Germany.

Nature
|November 11, 2005
PubMed
概括
此摘要是机器生成的。

果虫再生过程中的细胞身份变化与多组 (PcG) 蛋白调节有关. 氨基末端激酶 (JNK) 途径控制了这一过程,这种过程在哺乳动物中是保留的.

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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科学领域:

  • 发育生物学 发展生物学
  • 细胞生物学 细胞生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 细胞身份切换,称为转判定,发生在Drosophila影像盘再生过程中.
  • 像Wingless这样的形态基因可以诱导子宫外基因表达,改变细胞命运.
  • 多组 (PcG) 蛋白质通过调节基因表达来维持细胞身份至关重要.

研究的目的:

  • 为了研究转定和多组 (PcG) 蛋白调节之间的关系.
  • 阐明Jun氨基终端激酶 (JNK) 信号通路在转定性中的作用.

主要方法:

  • 对PcG和JNK突变Drosophila的转定性频率的分析.
  • 使用静音记者基因监测PCG功能.
  • 研究哺乳动物细胞中保存的调节相互作用.

主要成果:

  • 在PcG突变中,转判定频率增加.
  • 在转定细胞中,PcG功能是下调的.
  • 转基因确定需要JNK信号通路的激活,它的突变会降低频率.
  • 在哺乳动物细胞中保留了JNK和PcG之间的调节相互作用.

结论:

  • 转定事件与多组 (PcG) 调节相结合.
  • 氨基末端激酶 (JNK) 信号通路在再生过程中直接控制PcG下调.
  • 这种信号级联在细胞命运重塑中的作用在各个物种中得到保护.