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A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
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在甲状腺下出血后发生的急性神经心脏损伤
Nader M Banki1, Alexander Kopelnik, Michael W Dae
1Division of Cardiology, Department of Radiology, UCSF Medical Center, San Francisco, California, USA.
Circulation
|November 16, 2005
概括
在下大脑下出血 (SAH) 后的左心室功能障碍与异常的交感神经活动有关,而不是心脏血流减少. 这表明神经损伤可能会导致SAH患者的心肌问题.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 左心室 (LV) 静脉缩功能障碍是人类脑下垂体出血 (SAH) 患者已知的并发症.
- 这种功能障碍的确切原因是有争议的,包括心肌缺血和过度分类胺释放等理论.
研究的目的:
- 在SAH患者中调查LV缩功能障碍的潜在病理生理学.
- 为了区分心肌输液和交感内置异常.
主要方法:
- 在38个月的时间里,在42名SAH患者中使用心声和心肌扫描 (MIBI和MIBG).
- 测量心脏类素I (cTI) 水平,以评估肌细胞亡.
- 盲目观察员计算了LV射出分数和墙壁运动得分.
主要成果:
- 所有具有可解释扫描的患者 (N=41) 均显示心肌输液正常 (MIBI吸收).
- 十二名患者表现出异常的交感内置 (MIBG吸收缺失).
- 脱皮的患者更有可能出现LV壁运动异常 (92%对52%,P=0.030) 和升高的cTI (58%对21%,P=0.029).
结论:
- 在SAH中,LV缩功能障碍与正常的心肌输液,但异常的交感内置有关.
- 研究结果表明,从心脏交感神经中释放过多的北上腺素可能会导致肌细胞和神经末端损伤.
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