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怀孕的特征和母亲患乳腺癌的风险
Sven Cnattingius1, Anna Torrång, Anders Ekbom
1Department of Medical Epidemiology and Biostatistics, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden. sven.cnattingius@mep.ki.se
JAMA
|November 17, 2005
概括
怀孕期间胎盘体重较高与母亲患乳腺癌的风险增加有关. 这一发现支持怀孕激素在乳腺癌发展中的作用.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 怀孕涉及显著增加的荷尔蒙水平 (雌激素,孕激素),主要来自胎盘.
- 胎盘特征可以作为孕期母亲荷尔蒙暴露的间接标志物.
- 以前的研究表明,怀孕标志物与随后的母乳癌风险之间存在不一致的关联.
研究的目的:
- 调查怀孕期间荷尔蒙暴露的间接标志物,特别是胎盘体重和患乳腺癌的风险之间的关系.
- 探索其他妊娠特征与母亲乳腺癌风险之间的关联.
主要方法:
- 一项基于人口的队列研究,利用瑞典的健康登记 (出生登记,癌症登记,死亡原因登记,人口登记).
- 包括1982年至1989年间分娩单身婴儿的妇女,追踪至2001年.
- 使用Cox比例危险模型来分析胎盘体重和乳腺癌发病率之间的关联.
主要成果:
- 在314,019名女性中,有2216名女性患有乳腺癌;95%的女性在50岁之前被诊断出乳腺癌.
- 胎盘体重在一个怀孕期间为500-699克,在另一个怀孕期间为≥700克的妇女,风险增加了1.82倍.
- 在两次怀孕中,胎盘体重≥700克的妇女患乳腺癌的风险增加了2.05倍.
结论:
- 胎盘体重表明与母亲乳腺癌风险的积极关联.
- 这些发现强化了怀孕激素显著影响晚年患乳腺癌的风险的假设.
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