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Updated: Jul 13, 2026

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme
08:36

Separation of Mouse Embryonic Facial Ectoderm and Mesenchyme

Published on: April 12, 2013

GTF2IRD1在人类和小鼠的面发育中的作用

May Tassabehji1, Peter Hammond, Annette Karmiloff-Smith

  • 1Academic Unit of Medical Genetics, University of Manchester, St. Mary's Hospital, Manchester M13 9PL, UK. m.tassabehji@manchester.ac.uk

Science (New York, N.Y.)
|November 19, 2005
PubMed
概括

GTF2IRD1是面和认知发育中的关键基因. 在小鼠中缺少它会导致类似于人类威廉姆斯-比伦综合征的异常,揭示了对先天性缺陷的遗传洞察力.

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相关概念视频

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...