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Updated: Jul 7, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Published on: September 17, 2017

通过结合溶液小角度X射线散射和NMR数据来精制多域蛋白质结构

Alexander Grishaev1, Justin Wu, Jill Trewhella

  • 1Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. grishaev@speck.niddk.nih.gov

Journal of the American Chemical Society
|November 25, 2005
PubMed
概括

这项研究将小角度X射线散射 (SAXS) 数据与核磁共振 (NMR) 约束相结合,以改善3D蛋白质结构的确定. 综合方法提高了复杂的多域蛋白质的结构精度.

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X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...