相关实验视频
Updated: Jul 29, 2026

09:41
A Method For Production of Recombinant mCD1d Protein in Insect Cells.
Published on: December 10, 2007
通过CD1e对微生物甘油脂抗原处理的协助
Henri de la Salle1, Sabrina Mariotti, Catherine Angenieux
1INSERM, U725, Etablissement Francais du Sang-Alsace, F-67065 Strasbourg, France.
概括
可溶性CD1e处理像PIM6这样的真菌细菌甘油脂,使CD1b受限T细胞能够识别它们. 这种由CD1e编辑的甘油脂扩大了T细胞抗原的范围,从而改善了抗菌免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 葡萄糖脂抗原呈现方式
- T细胞的识别功能
背景情况:
- CD1分子向T细胞呈现甘油脂抗原.
- 作为CD1家族成员的CD1e的功能在很大程度上是未知的.
- 特定的T细胞识别CD1分子的复合体与自身或微生物甘油脂.
研究的目的:
- 为了确定CD1e在免疫反应中的功能.
- 研究CD1e在菌根抗原的处理和呈现中的作用.
- 了解CD1e如何影响T细胞对糖脂的识别.
主要方法:
- 研究了CD1e,甘油脂 (PIM6) 和T细胞之间的相互作用.
- 使用溶解体α-曼诺酶进行抗原处理.
- 采用重组CD1e来评估其结合和酶活性.
- 研究了对受CD1b限制的T细胞的刺激.
主要成果:
- 对于CD1b受限制的T细胞刺激, lysosomal alpha-mannosidase必须部分消化六氨基基酸酸-myo-inositols (PIM6).
- 溶性CD1e对于这种PIM6处理至关重要.
- 再组合的CD1e证明了结合甘油脂和促进PIM6消化的能力.
- CD1e充当"糖脂编辑器"的作用.
结论:
- CD1e在处理和编辑糖脂抗原中起着至关重要的作用.
- 这种CD1e的编辑功能扩大了糖脂性T细胞抗原的谱.
- CD1e通过增强T细胞对加工的甘油脂的识别来优化抗微生物免疫反应.
相关概念视频
Cell-mediated Immune Responses
Overview
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Presenting Cells
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

