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相关概念视频

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

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Updated: Jul 6, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
09:30

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核 accumbens 长期抑郁和表达行为敏感化的表达.

Karen Brebner1, Tak Pan Wong, Lidong Liu

  • 1Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.

Science (New York, N.Y.)
|November 29, 2005
PubMed
概括

研究人员确定了药物成背后的分子机制. 阻断细胞核中的特定受体内细胞结合,可以防止大鼠对安非他命诱导的行为敏感化,从而提供了对药物依赖神经可塑性的见解.

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 成研究 研究成研究

背景情况:

  • 药物成和精神分裂症涉及药物依赖的神经可塑性,模仿动物的行为敏感化.
  • 驱动行为敏感化的精确分子机制在很大程度上仍未定义.
  • 长期抑郁 (LTD) 的α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid受体 (AMPAR) 介导的突触传播是学习和记忆的潜在细胞基础.

研究的目的:

  • 阐明行为敏感化背后的分子机制.
  • 为了研究AMPAR内细胞在核 (NAc) 在行为敏感化中的作用.

主要方法:

  • 在NAc中研究了后突触AMPARs的克拉林依赖性内细胞结合.
  • 利用动氨酸衍生物和GluR2衍生物来分别抑制克拉斯林介导和调节的AMPAR内细胞分裂.
  • 系统地或直接向大鼠的NAc注入,以评估对安非他命诱导的行为敏感化的影响.

主要成果:

  • 在NAc中LTD的表达取决于后突触AMPARs的克拉特林介导的内细胞分裂.
  • 克拉特林介导的内细胞酶抑制或受调控的AMPAR内细胞酶阻断NAc LTD.
  • 在大鼠中,通过膜透的GluR2的全身或NAC内给药消除了安非他胺诱导的行为敏感性.

结论:

  • 在NAc中调节的AMPAR内细胞化是表达行为敏感化的关键分子机制.
  • 向AMPAR内细胞突变途径可能为治疗药物成和相关疾病提供新的治疗策略.