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Updated: Apr 10, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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TWEAK减轻了从先天性免疫到适应性免疫的过渡

Heather Maecker1, Eugene Varfolomeev, Frank Kischkel

  • 1Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Cell
|December 6, 2005
PubMed
概括

瘤亡因子类弱诱导细胞亡 (TWEAK) 蛋白抑制天生的免疫力,减少自然杀手 (NK) 细胞活性和干扰素- (IFN-γ) 生产. 这种TWEAK功能限制了向适应性T助手1 (TH1) 免疫反应的过渡.

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