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对于β-lactams和类似β-sultams与氨酸β-lactamases反应的不同过渡状态结构

Wing Y Tsang1, Naveed Ahmed, Paul S Hinchliffe

  • 1Department of Chemical and Biological Sciences, The University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.

Journal of the American Chemical Society
|December 8, 2005
PubMed
概括

N-acylβ-sultams通过硫化来禁用C类β-乳酸酶,在机理上与β-lactams不同. 这些新型抑制剂在酶反应中显示出不同的过渡状态,为β-乳酸酶抑制提供了洞察力.

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