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相关概念视频

Temperature Measurement Sites01:14

Temperature Measurement Sites

A thermometer measures body temperature. The common sites for measuring body temperature are the oral cavity, axillary region, temporal artery, and skin surface, such as the forehead, abdomen, and axilla. True core body temperature is assessed in the rectum, tympanic membrane, pulmonary artery, esophagus, and urinary bladder.
Oral: When assessing oral temperature, the thermometer tip should be placed under the tongue in the posterior sublingual pocket. It offers accurate readings and can be...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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相关实验视频

Updated: Jul 7, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
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Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

基于PARACEST剂的MRI温度计

Shanrong Zhang1, Craig R Malloy, A Dean Sherry

  • 1Advanced Imaging Resonance Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8568, USA. zhangs@u.washington.edu

Journal of the American Chemical Society
|December 15, 2005
PubMed
概括

一种新的磁共振成像 (MRI) 温度测量方法使用 PARACEST 剂来测量温度. 与传统的质子共振频率 (PRF) 温度计相比,这种技术显著提高了温度灵敏度.

科学领域:

  • 生物医学工程 生物医学工程
  • 化学物理 化学物理
  • 医疗成像医学成像

背景情况:

  • 准确的温度监测对于各种医疗应用至关重要,包括高温治疗癌症.
  • 现有的MRI温度计方法,如质子共振频率 (PRF) 温度计,在灵敏度和准确度方面存在局限性.
  • PARACEST 剂具有独特的特性,可以用于新型成像应用.

研究的目的:

  • 开发和演示一种新的体外MRI温度测量技术,使用PARACEST药物.
  • 为了评估PARACEST剂的温度依赖的化学转移,用于温度计.
  • 将新技术的性能与传统的PRF温度计进行比较.

主要方法:

  • 使用了一种新的PARACEST (PARAmagnetic化学交换和转移) 剂用于MRI温度计.
  • 对两个原型 (Dy(1) 3+和 Eu(2)-) 的Ln3+结合的水分子化学转移的线性温度依赖性进行了研究.
  • 测量温度依赖在20-50摄氏度的范围内.

主要成果:

  • 对于 Dy(1) 3+ 和 Eu(2) - PARACEST 剂,温度和化学变化之间有线性关系.
  • 与水PRF温度计 (-0.01ppm/°C) 相比,实现了显著改善的温度依赖性 (约为690倍和40倍).

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  • 化学转移方程被确定为delta = 6.9 x T - 944.7对于Dy(1) 3+和delta = -0.4 x T + 64.6对于Eu(2) -.
  • 结论:

    • 基于PARACEST的新型MRI温度计技术显示出对准确和灵敏的温度监测有很大的前景.
    • 这种方法比现有的PRF温度计提供了实质性的改进,可能使新的临床应用成为可能.
    • 需要进一步的研究和体内验证来探索这种技术的全部潜力.