在双面玻表面上进行有机合成:具有十二倍功能的密合体结构
Tiejun Li1, Satish S Jalisatgi, Michael J Bayer
1Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA.
Journal of the American Chemical Society
|December 15, 2005
概括
通过使用各种方法合成了新型与结合的集群,称为闭合体. 使用1.1'-carbonyldiimidazole激活的碳素酸的一般策略被证明是有效的,用于创建这些多功能集群衍生物.
科学领域:
- 无机化学 无机化学
- 材料科学 材料科学 材料科学
- 集团化学 集团化学
背景情况:
- [closo-B12(OH) [12]2-集群是一种独特的二面体结构,具有潜在的应用.
- 集群的功能化对于调整它们的特性至关重要.
- 乙链接为修改集群表面提供了一条通用途径.
研究的目的:
- 开发和描述新型结衍生物的合成方法[closo-B12(OH) 12) 2-集群 (闭合体).
- 建立一个通用和高效的合成策略来制造这些密闭体.
- 证明开发的方法与各种外围功能组的兼容性.
主要方法:
- 双甲基) - - 克洛索-多德卡基-多德卡酸与活性炭酸,酸化物,无水化物和乙烯基的反应.
- 作为一般的策略,利用1.1'-carbonyldiimidazole (CDI) 进行碳酸激活.
- 使用高温和高压来加速合成.
- 使用固定清除剂试剂,以有效净化闭合体.
主要成果:
- 通过使用多种合成途径成功合成了二二甲的闭合体.
- 确定1.1'-碳基胺醇方法作为一种通用和可靠的合成策略.
- 证明与各种外围功能群的兼容性,包括终端氨基群.
- 制备并随后乙化一个含有十二个末端氨基基组的闭合体.
结论:
- 开发了用于新型结聚衍生物 (闭合) 的多功能合成方法.
- 1,1'-碳乙烯胺醇激活方法是密封体合成的强大和可通用的方法.
- 该方法允许纳入各种功能组,扩大集群的潜在应用.
相关概念视频
01:12Carbon Skeletons
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
01:54What are Membranes?
A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and Golgi...
02:34Structural Isomerism
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
01:24What are Membranes?
A cell's plasma membrane demarcates the cell's borders and determines the nature of its interaction with the environment. Cells exclude certain substances, take in others, and excrete some others in controlled quantities. The plasma membrane must be flexible to allow certain cells, such as red and white blood cells, to change their shape while passing through narrow capillaries. These are the more obvious plasma membrane functions. In addition, the plasma membrane's surface carries markers that...
02:06Newman Projections
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
01:16Structure of Conjugated Dienes
Introduction
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...