柴油废气的吸入会导致血管功能障碍和内源性纤维解质受损
Nicholas L Mills1, Håkan Törnqvist, Simon D Robinson
1Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland. nick.mills@ed.ac.uk
吸入柴油废气会损害人体血管功能,影响血管度和血液凝固. 这项研究表明,空气污染与心脏病发作风险之间存在联系.
科学领域:
- 环境健康 环境健康
- 心血管生理学心血管生理学
- 毒理学 毒理学 毒理学
背景情况:
- 交通污染的空气污染被怀疑会引发急性心肌梗塞.
- 将空气污染与心血管事件联系在一起的机制尚不清楚.
研究的目的:
- 调查柴油废气吸入对人类血管和内皮功能的影响.
- 探索空气污染引起的心血管事件的潜在机制.
主要方法:
- 这是一项双盲,随机,交叉研究,涉及30名健康男性.
- 在间歇性运动期间暴露于稀释的柴油废气或空气1小时.
- 测量前臂血流和炎症标志物与血管扩展剂输液暴露后.
主要成果:
- 柴油排气暴露没有改变静止血液流动或炎症标志物.
- 在柴油暴露后2小时和6小时,血管扩张剂诱导的血流反应减弱.
- 布拉迪基宁诱导的组织等离子素激活剂释放被抑制在柴油暴露后6小时.
结论:
- 吸入稀释柴油废气会损害人体血管调和内源性纤维解.
- 研究结果表明,有机制将城市空气污染与动脉血症和心肌梗塞联系起来.
- 在环境相关的度下,柴油废气暴露会影响关键的血管功能.
更多相关视频
07:09Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
10:11Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
Published on: October 22, 2014
相关概念视频
Peripheral Artery Disease I: Introduction
Venous Thrombosis I: Introduction
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Clot Retraction and Fibrinolysis
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
