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相关概念视频

Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Buffer Systems in the Body01:19

Buffer Systems in the Body

Chemical buffers play a critical role in the body's regulation of pH levels. These systems contain one or more compounds that stabilize pH changes by neutralizing strong acids or bases. When pH levels drop, hydrogen ions bind to a weak base; when pH levels rise, hydrogen ions are released. This dynamic process helps maintain pH within a narrow and stable range essential for normal physiological function.
A typical buffer system in bodily fluids includes a weak acid and its corresponding anion,...
Protein Buffers in Blood Plasma and Cells01:20

Protein Buffers in Blood Plasma and Cells

The human body utilizes protein buffer systems to maintain a stable pH. These systems capitalize on the dual role of amino acids, which can act as acids or bases by accepting or releasing hydrogen ions in response to pH changes. Protein buffer systems are particularly significant in the extracellular fluid (ECF) and intracellular fluid (ICF) of active cells, where structural and functional proteins provide substantial buffering capacity.
Certain amino acids can exist in a zwitterion state at a...

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相关实验视频

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by &#960;-&#960; Stacking Interactions
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基于生物相容的zwitterionic diblock共聚合物的pH敏感囊泡.

Jianzhong Du1, Yiqing Tang, Andrew L Lewis

  • 1Department of Chemistry, The University of Sheffield, Brook Hill, Sheffield S3 7HF, United Kingdom.

Journal of the American Chemical Society
|December 22, 2005
PubMed
概括

从一个zwitterionic共聚合物 (PMPC-b-PDPA) 中创建了生物相容的pH敏感囊泡. 这些自我组装的聚合物囊泡响应pH值的变化,形成适合潜在生物医学应用的稳定结构.

科学领域:

  • 聚合物化学 聚合物化学
  • 材料科学 材料科学 材料科学
  • 生物技术是生物技术.

背景情况:

  • 生物相容材料对于先进的药物输送系统至关重要.
  • 对pH敏感的聚合物为控制释放应用提供了可调节的特性.
  • 自组装的双块共聚物为纳米结构制造提供了一个多功能平台.

研究的目的:

  • 为了合成和表征新的pH敏感的双块共聚合物囊泡.
  • 为了研究聚[2-(methacryloyloxy) 乙烯酸胆-块-2-(diisopropylamino) 乙烯甲基酸盐] (PMPC-b-PDPA) 的自组装行为.
  • 探索这些囊泡在纳米粒子装饰方面的潜力.

主要方法:

  • 双块共聚合物的合成和表征.
  • 囊泡的pH诱导的自我组装.
  • 传输电子显微镜 (TEM) 用于形态分析.
  • 动态光散射 (DLS) 用于尺寸的确定.
  • 紫外线可见光谱光度计用于表征.
  • 通过化学还原来装饰金纳米粒子.

主要成果:

  • 在pH值从2变为6以上时,PMPC-b-PDPA自发形成高度生物相容,pH值敏感的囊泡.

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Published on: October 10, 2016

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

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Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

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  • 疏水性PDPA链形成了囊泡壁,证明了对pH反应的组合.
  • 鉴定证实了囊泡的形成,大小和稳定性.
  • 通过金纳米颗粒成功地装饰了囊泡.
  • 结论:

    • PMPC-b-PDPA双块共聚合物可以自组装成生物相容,pH敏感的囊泡.
    • 这些囊泡表现出基于溶液pH值的调节性形成.
    • 装饰的囊泡显示出在纳米医学和诊断领域的应用潜力.