动物进化和辐射的分子特征被压缩在时间内
Antonis Rokas1, Dirk Krüger, Sean B Carroll
1Howard Hughes Medical Institute, Laboratory of Molecular Biology, R. M. Bock Labs, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA.
概括
由于迅速的早期辐射,甲动物的遗传关系仍然不确定. 这种压缩的进化历史,与真菌不同,表明密切间隔的基遗传事件,即使有广泛的基因序列数据.
科学领域:
- 进化生物学 进化生物学
- 人类遗传学 是一个学科.
- 基因组学就是基因组学.
背景情况:
- 进化史和甲动物类之间的关系在很大程度上尚未解决.
- 了解早期动物进化对于理解生物多样性至关重要.
研究的目的:
- 通过大规模基因测序来研究甲基动物类之间的遗传关系.
- 为了比较元类动物的遗传学与其他古代类的分辨率,如真菌.
主要方法:
- 获取来自各种元动物种群的广泛基因序列数据,包括研究不足的群体.
- 对序列数据的遗传学分析,以推断进化关系.
- 与具有相似进化年龄的真菌群进行比较的基因分析.
主要成果:
- 尽管有大量的数据,但大多数甲动物类的遗传关系仍然没有得到解决.
- 同样的基因在一个主要的真菌群体内强有力的解决了家族遗传关系.
- 分辨率的差异表明,在早期的metazoan历史中,一个快速的,时间压缩的辐射事件.
结论:
- 甲基动物缺乏遗传学分辨率很可能是由于其历史早期发生的快速辐射事件.
- 这一发现与古生物学证据一致,表明早期动物的压缩进化时间表.
- 模拟分析支持,快速辐射的特征是密切间隔的克拉多基因事件,即使有足够的序列数据,也会导致未解决的族系.
相关概念视频
Speciation Rates
Speciation can proceed at markedly different rates, and evolutionary biologists commonly describe these differences through the models of gradualism and punctuated equilibrium. Both patterns explain how new species arise, but they differ in the tempo and continuity of evolutionary change. In both cases, evolutionary change arises from heritable variation within populations, with natural selection often shaping traits that improve survival and reproduction under specific environmental conditions.
Convergent Evolution
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.The structures that arise from convergent evolution are called analogous structures. They are similar in function even if they are dissimilar in structure. Further, structures can be analogous while also...
Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
Protein Diffusion in the Membrane
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
Protein Dynamics in Living Cells
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...


