骨髓细胞中循环氧基因酶-1缺乏会增加阿波利波蛋白E和低密度脂蛋白受体-null小鼠的早期动脉样硬化

Vladimir R Babaev1, Lei Ding, Jeff Reese

  • 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. vladimir.babaev@vanderbilt.edu

Circulation
|December 29, 2005
PubMed
概括

骨髓细胞中循环氧基因酶-1 (COX-1) 缺乏会使小鼠的动脉样硬化恶化. 这表明血小板血栓素的产生不会促进早期病变的形成,而巨细胞中的COX-2上调是益风性.

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