深静脉血栓症中的血栓回归. 用双重扫描量化自发血栓溶解的量化
B van Ramshorst1, P S van Bemmelen, H Hoeneveld
1Department of Surgery, St. Antonius Hospital, Nieuwegein, Holland.
Circulation
|August 1, 1992
概括
肝素治疗在急性深静脉血栓症 (DVT) 中促进显著的血栓回归. 双重扫描有效量化了这种回归,重新道化发生在早期,并受到初始血栓负荷的影响.
科学领域:
- 血管医学 血管医学
- 诊断成像 诊断成像 诊断成像
- 血栓形成研究研究
背景情况:
- 在治疗肝素的急性深静脉血栓症 (DVT) 中的血栓回归缺乏全面的文档.
- 现有的文献报告了血栓解脱和再通道化的变化率.
研究的目的:
- 用双重扫描来前性评估急性股骨深静脉血栓症中的血栓回归.
- 量化血栓分离和再通道化的速度和特征.
主要方法:
- 一项前性后续研究,涉及18名患有急性股骨状心脏病的患者.
- 双重扫描在1,3,6,12和26周对80个静脉段进行.
- 分析不同静脉段的血栓负荷,回归和再通道率.
主要成果:
- 在所有静脉段以指数级的速度观察到显著的血栓回归 (p < 0.001).
- 脊柱静脉段具有最高的初始血栓负荷.
- 在23/31个封闭的段落中发生了再通道化,主要是在6周内,并且依赖负载.
- 血栓扩张发生在15个段,尽管抗凝,与初始负载或静脉段无关.
结论:
- 双重扫描是一种有价值的非侵入性工具,用于在急性DVT中详细量化血栓回归.
- 血栓分辨率和再通道化率受到初始血栓负担的影响.
- 在所有病例中,抗凝固药物治疗并不能防止血栓扩张.
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