与年龄和健康男性的运动训练相关的对异二醇的心血管反应的差异
J R Stratton1, M D Cerqueira, R S Schwartz
1Department of Medicine, Seattle VA Medical Center, WA 98108.
Circulation
|August 1, 1992
概括
心脏衰老会降低健康男性对β-agonist刺激的反应,影响心率,血压和排泄率. 运动训练并没有改善这些与年龄相关的β-上腺素下降.
科学领域:
- 心脏病学 心脏病学
- 老年学是指老年学的学科.
- 运动生理学 运动生理学
背景情况:
- 心脏衰老与降低对β-agonist刺激的心率反应有关.
- 衰老对射出分数和其他心血管对人类β-激动剂的反应的影响尚不清楚.
- 运动训练有助于改善这些与年龄相关的β-agonist反应的潜力仍未确定.
研究的目的:
- 在健康男性中调查与年龄相关的心血管对异二醇反应的差异.
- 为了确定耐力运动训练是否可以增强老年和年轻男性的β-上腺体心血管反应.
主要方法:
- 对分级异二醇输注的心血管反应在年轻和年长的健康男性中被测量.
- 参与者接受了6个月的耐力训练,随后重新测试了心血管反应.
- 评估了最大的氧气消耗,以评估训练效果.
主要成果:
- 与年轻男性相比,老年男性对异二醇的心率,缩血压,腹缩血压,喷射率和心脏输出反应显著降低.
- 强化耐力训练在两个年龄组都增加了最大的氧气消耗,但没有改变对异二醇的心血管反应.
- 血中异二醇度在各组之间相似,在训练后没有变化.
结论:
- 健康的衰老与心血管对β-上腺素刺激的反应下降有关,包括心率,血压,射出分数和心脏输出.
- 这些改变的β-上腺素反应可能导致老年人最大运动期间心脏功能减弱.
- 强烈的运动训练并不能逆转与年龄相关的β-上腺体心血管反应能力的下降.
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