强力频率关系对在有意识的狗体育运动期间的左心室功能的影响
T Miura1, S Miyazaki, B D Guth
1Yamaguchi University, Japan.
Circulation
|August 11, 1992
概括
运动显著增强了对有意识动物心肌收缩力的力频效应. 运动期间心率减慢会降低收缩性,这表明有明显的负面无otropic 影响.
科学领域:
- 心血管生理学心血管生理学
- 运动生理学 运动生理学
背景情况:
- 强力频率对心肌收缩率的影响在静止状态下得到了很好的研究.
- 它在运动期间对有意识的动物的影响在很大程度上尚未评估.
研究的目的:
- 为了评估强力频率对意识犬在运动期间心肌收缩性的影响.
- 为了确定运动是否会改变内热态状态对心率变化的反应.
主要方法:
- 八只有意识的狗被仪器用于左心室 (LV) 压力和体积,以及大动脉压力测量.
- 跑步机上进行了运动,心率 (HR) 通过肌心药物和心房节拍来操纵.
- 在运动期间,在不同的HR中评估了LV收缩性和放松参数.
主要成果:
- 将运动HR从每分钟240次减慢到每分钟150次,显著降低了LV收缩性.
- 像LV最大阳性dP/dt和 (dP/dt) DP40这样的指标下降,而心室松 (tau) 延长.
- 节拍平均的末缩压力-体积点向下和向右移动,HR减少.
结论:
- 运动显著增强了力频效应对完整的左心室的无otropic状态.
- 在运动期间减慢心率会产生显著的负面内托普影响.
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