慢性减少心肌缺血并不能减轻迷你葡萄中冠状动脉附带病的发展
J D Symons1, K F Pitsillides, J C Longhurst
1Department of Internal Medicine, University of California, Davis 95616.
Circulation
|August 1, 1992
概括
心肌缺血可能不会驱动冠状动脉附带循环的发展. 用β-阻断剂降低氧气需求并没有改变附带细胞的生长,这表明缺血程度与这种猪模型中的附带细胞发展无关.
科学领域:
- 心血管生理学心血管生理学
- 缺血性心脏病研究 缺血性心脏病研究
- 冠状动脉循环 冠状动脉循环
背景情况:
- 心肌缺血是冠状动脉附带循环发展的已知刺激因素.
- 这项研究调查了减少心肌氧需求是否会影响附带增长.
- 使用一种猪模型,该模型中出现了由阿米洛伊德诱导的左环冠状动脉收缩.
研究的目的:
- 为了测试慢性减少心肌氧需求减弱冠状动脉附带发育的假设.
- 为了评估心肌缺血和8周的附带循环增长之间的关系.
- 评估β-上腺受体阻断对附带发育的功能影响.
主要方法:
- 在猪中,使用的左环冠状动脉 (LCx) 是由阿米洛因引起的收缩.
- 通过心肌血流 (放射性微球) 和区域功能 (声微仪) 评估了附带的发展.
- 用普拉诺洛尔进行β-腺受体阻塞,以减少心肌中氧气需求,并评估其影响.
主要成果:
- 贝塔腺素受体阻塞显著降低了心肌功能障碍的指标,表明缺血减少.
- 在第5周和第8周,在未接受治疗的组和被治疗的组之间没有观察到血液流量比率或缩壁的显著差异.
- 在练习期间的功能评估显示,两组的反应相似,表明了可比的附带发展.
结论:
- 在运动期间功能性测量冠状动脉附带循环的发展与心肌缺血的程度和持续时间无关.
- 这项研究的结果挑战了传统的看法,即缺血是附带生长的唯一驱动因素.
- 结果表明,其他因素可能会显著影响冠状动脉附带形成.
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