类药物和癌症风险:一个元分析
Krista M Dale1, Craig I Coleman, Nickole N Henyan
1University of Connecticut School of Pharmacy, Storrs, Conn, USA.
JAMA
|January 5, 2006
概括
根据对随机对照试验的审查,用于降低胆固醇的他类药物似乎无法预防癌症或减少癌症死亡. 在所有癌症类型和他类药物亚型中观察到这种中性效应.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 类他类药物是广泛处方的降胆固醇药物,在预防心脏事件方面具有既定的益处.
- 来自回顾性研究的新兴证据表明,他类药物在预防癌症方面可能发挥作用.
研究的目的:
- 系统评估他类药物治疗对癌症发病率和死亡率的影响.
- 分析他类药物对特定癌症类型和不同他类药物配方 (脂性与水性,天然与合成) 的影响.
主要方法:
- 在多个数据库 (MEDLINE,EMBASE等) 中进行了全面的文献搜索. 在2005年7月之前.
- 包括26项随机对照试验 (RCT) 的数据,涉及86,936名参与者,重点关注癌症发病率和死亡.
- 用随机效应模型进行了元分析,以计算赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 对6662例发生癌症和2407例癌症死亡的元分析显示,在使用他类药物时,癌症发病率 (OR,1.02;95% CI,0.97-1.07) 或癌症死亡率 (OR,1.01;95% CI,0.93-1.09) 没有显著减少.
- 没有任何特定的癌症类型显示发生率或死亡率降低.
- 这种中性效应在水友性,脂友性,自然衍生的和合成衍生的他类药物中是一致的.
结论:
- 随机对照试验表明,他类药物对患癌症和癌症相关死亡风险具有中性影响.
- 类固醇治疗似乎没有影响任何特定癌症类型的发病率或死亡率.
- 不同类型的他类药物也没有对癌症风险产生影响.
更多相关视频
07:32Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
Published on: April 12, 2024
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
相关概念视频
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Cholesterol: Significance and Regulation
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
