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胆酸通过促进细胞内甲状腺激素激活诱导能量消耗

Mitsuhiro Watanabe1, Sander M Houten, Chikage Mataki

  • 1Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404 Illkirch, France.

Nature
|January 10, 2006
PubMed
概括

胆酸 (BAs) 通过激活TGR5受体,增加cAMP,并诱导2型甲酸氨酸二氧化酶 (D2) 来增加能量消耗. 这一途径在代谢组织中打击肥胖和胰岛素抵抗.

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