延迟生育和不良围产期结局的风险. 一个基于人口的研究
S Cnattingius1, M R Forman, H W Berendes
1Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
JAMA
|August 19, 1992
概括
延迟生育增加了不良妊娠结果的风险,包括胎儿死亡和低出生体重,即使在健康的妇女中. 这项研究强调了在产前护理中考虑母亲年龄的重要性.
科学领域:
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 提前孕产妇年龄是全球日益增长的趋势.
- 孕产妇年龄对怀孕结果的影响需要继续调查,特别是在健康的绝育妇女身上.
- 以前的研究可能没有完全调整混因素.
研究的目的:
- 检查晚期母亲年龄与怀孕结果之间的关联.
- 专门评估健康的第一次母亲的风险.
- 为了控制人口,生活方式和医疗混因素.
主要方法:
- 基于人口的队列研究,利用从瑞典医疗出生登记处前性收集的数据.
- 其中包括173715名20岁及以上的北欧女性,她们在1983-1987年间分娩了独生子.
- 分析了晚期胎儿死亡率,非常低出生体重 (VLBW),中度低出生体重 (MLBW),非常早产,中度早产和小于妊娠年龄 (SGA) 的婴儿.
主要成果:
- 与20-24岁女性相比,30-34岁女性的晚期胎儿死亡,VLBW,MLBW,非常早产和SGA婴儿的几率增加.
- 在35-39岁和40岁以上的妇女中,VLBW,MLBW,非常早产,中度早产和SGA婴儿的风险显著更高.
- 先进的孕产妇年龄与多种不良周产期结果的高概率比率相关.
结论:
- 延迟生育与更高的不良妊娠结果发生率有关.
- 这些风险仍然存在,即使考虑到母亲的并发症和其他已确定的风险因素.
- 这些发现强调了为老年母亲量身定制的产前护理策略的必要性.
相关概念视频
Population Growth
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.However, realistic environmental conditions limit the number of...
Regression Toward the Mean
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Meiosis vs. Mitosis
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...


