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细菌RNA和小型抗病毒化合物通过皮林/Nalp3激活caspase-1

Thirumala-Devi Kanneganti1, Nesrin Ozören, Mathilde Body-Malapel

  • 1University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.

Nature
|January 13, 2006
PubMed
概括

低氨酸 (CIAS1) 对于激活caspase-1和产生IL-1beta (IL-1beta) 和IL-18在对细菌RNA的反应中至关重要. 这一发现揭示了自身炎症综合征.

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