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Updated: Jul 10, 2026

Identification of Growth Inhibition Phenotypes Induced by Expression of Bacterial Type III Effectors in Yeast
09:34

Identification of Growth Inhibition Phenotypes Induced by Expression of Bacterial Type III Effectors in Yeast

Published on: March 30, 2010

鉴定一种具有G蛋白仿真功能的细菌III型效应器家族

Neal M Alto1, Feng Shao, Cheri S Lazar

  • 1Department of Pharmacology, Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|January 18, 2006
PubMed
概括

细菌病原体注入效应蛋白,模仿宿主细胞信号GTPase,如RhoA,Rac1和Cdc42. 这些对感染至关重要的功能模仿者,使用保存的WxxxE动机进行活动.

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Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing10:29

Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing

Published on: July 6, 2016

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G-protein Coupled Receptors

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G Protein-coupled Receptors

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Activation and Inactivation of G Proteins

Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high affinity and are together...
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