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相关实验视频

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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

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Published on: October 16, 2010

勃起功能障碍和随后的心血管疾病.

Ian M Thompson1, Catherine M Tangen, Phyllis J Goodman

  • 1Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. thompsoni@uthscsa.edu

JAMA
|January 18, 2006
PubMed
概括
此摘要是机器生成的。

勃起功能障碍 (ED) 与55岁以上男性心血管事件的风险更高有关. 勃起障碍可能是潜在心血管疾病的信号,需要进行风险因素评估和干预.

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科学领域:

  • 心脏病学 心脏病学
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 预防医学 预防医学

背景情况:

  • 心血管疾病 (CVD) 和勃起功能障碍 (ED) 具有共同的风险因素.
  • 调查ED和随后的心血管疾病之间的联系对于早期检测和预防至关重要.

研究的目的:

  • 检查勃起功能障碍与随后心血管疾病的发生之间的关联.
  • 为了确定ED是否可以作为心血管事件的早期指标.

主要方法:

  • 来自前列腺癌预防试验 (安慰剂组) 的9457名55岁以上的男性队列被监测心血管疾病和ED.
  • 使用比例危险回归模型来分析相关性,并对多个共变量进行调整.
  • 数据收集发生在1994年至2003年之间,定期进行3个月的随访.

主要成果:

  • 在47%的没有先前存在心血管疾病的男性中,在研究开始时勃起功能障碍普遍存在.
  • 5年后发生的ED与随后心血管事件的风险增加25%有关 (HR=1.25,P=.04).
  • 患有流行性或偶发性ED的男性患心血管事件的风险高出45% (HR=1.45,P<.001),与吸烟或心肌梗塞家族病史的风险相比.

结论:

  • 勃起功能障碍可能是男性心血管临床事件的早期预警信号.
  • 勃起障碍的存在需要对心血管风险因素进行彻底的调查和管理.