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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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表观遗传沉声器和Notch合作通过沉默Rb来促进恶性瘤

Dolors Ferres-Marco1, Irene Gutierrez-Garcia, Diana M Vallejo

  • 1Instituto de Neurociencias CSIC-UMH, Campus de San Juan, Apartado 18, 03550 Sant Joan, Alicante, Spain.

Nature
|January 27, 2006
PubMed
概括

研究人员确定了两种表观遗传沉声器,Pipsqueak和Lola,涉及癌症的发展. 它们的放松调节,以及达过度表达,通过影响基因素修饰和DNA甲基化,促进转移性瘤的形成.

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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