该evi5瘤基因通过稳定阿纳促进复合抑制剂emi1来调节环林积累
Adam G Eldridge1, Alexander V Loktev, David V Hansen
1Department of Cancer Biology, Stanford University School of Medicine, CA 94305, USA.
Cell
|January 28, 2006
概括
瘤基因Evi5稳定了促进酶复合体/循环体 (APC/C) 抑制剂Emi1,防止过早的细胞循环进展. 在 Evi5 中使用.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 瘤基因是一种瘤基因.
背景情况:
- 亚纳酶促进复合体/循环体 (APC/C) 对于细胞循环进展至关重要.
- 艾米1是APC/C的关键抑制剂,调节进入线粒分裂的过程.
- 保持适当的Emi1水平对于防止细胞循环错误至关重要.
研究的目的:
- 为了确定Emi1积累的调节者.
- 阐明Evi5控制Emi1稳定的机制.
- 了解Evi5在维持细胞周期忠实性中的作用.
主要方法:
- 同免疫沉用于识别Emi1结合蛋白.
- 对蛋白质降解途径的分析.
- 细胞循环分析和中心体复制试验.
主要成果:
- 鉴定出Evi5是一种稳定Emi1的Emi1结合蛋白.
- Evi5对抗SCF ((betaTrCP) 介导的Emi1无化和降解.
- Evi5 除导致早期的 APC/C 激活,细胞循环停止和线粒体灾难.
结论:
- 在S/G2阶段,Evi5作为Emi1的关键稳定因子.
- 在Evi5和Polo类激酶活动之间的平衡调节了Emi1和环林水平.
- 这种平衡对于确保准确的细胞循环进展和线粒体忠实性至关重要.
相关概念视频
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Loss of Tumor Suppressor Gene Functions
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...


