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Updated: May 10, 2026
10:40
Homing of Hematopoietic Cells to the Bone Marrow
Published on: March 18, 2009
来自交感神经系统的信号调节了来自骨髓的造血干细胞的退出
Yoshio Katayama1, Michela Battista, Wei-Ming Kao
1Department of Medicine, Immunobiology Center and Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Cell
|January 28, 2006
概括
神经系统控制血液造血干细胞从骨髓出来的过程. 上腺素信号调节干细胞动员,这对于移植至关重要.
科学领域:
- 干细胞生物学 干细胞生物学
- 神经科学是一个神经科学.
- 血液形成 血液形成 血液形成
背景情况:
- 造血干细胞和原始细胞 (HSPCs) 位于骨髓 (BM) 中,受到CXCL12的吸引.
- 从BM转移HSPC对于干细胞移植至关重要.
研究的目的:
- 为了调查神经系统在HSPC从BM领域的退出中所扮演的角色.
- 阐明神经系统调节干细胞调动的机制.
主要方法:
- 使用了具有异常神经传导性的UDP-银糖胺银酸转移酶缺陷 (Cgt(-/-)) 小鼠.
- 给药颗粒细胞殖民地刺激因子 (G-CSF) 和富可伊丹以评估HSPC退出.
- 进行了上腺神经传递的药理和遗传性废除.
- 研究了β(2) 上腺激动剂对HSPC调动的影响.
主要成果:
- 在G-CSF或fucoidan给药后,Cgt(-/-) 小鼠几乎没有显示HSPC从BM出口.
- 在Cgt(-/-) 小鼠中,上腺,骨质细胞功能和骨CXCL12的调节失调.
- 发现,上腺素 (NE) 信号控制了G-CSF诱导的骨质细胞抑制,骨CXCL12下调和HSPC调动.
- 在对照小鼠和缺乏NE的小鼠中,Beta(2) 上腺激动剂的使用增强了HSPC的调动.
结论:
- 交感神经系统关键调节强迫HSPC从BM的退出.
- 上腺素信号传递是干细胞调动的关键调解者,通过影响骨质母细胞和CXCL12.
- 向上腺素通路可能为干细胞移植提供新的策略.
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